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Bovine leukaemia virus RNA packaging signal
This family represents the bovine leukaemia virus RNA encapsidation (packaging) signal, which is essential for efficient viral replication.
==Discovery==
Before its discovery, the location of the encapsidation (packaging) signal within the bovine leukaemia virus (BLV) was suggested by Manksy ''et al''. to either be “between the major splice donor site (in the r region of the viral RNA) and the ''gag'' start codon or between the primer binding site (located just downstream of the 5’ LTR) and the ''gag'' start codon.” In 1994, researchers from the University of Wisconsin Medical School made mutations in various locations of BLV through a process known as deletion analysis to determine if viral replication efficiency would be affected. They found mutants made with deletions in the 5’ end of the ''gag'' gene and in the 5’ untranslated leader region had a 7-fold and a 50-fold decrease in replication respectively. In contrast, they did not find a significant decrease in viral replication in mutants made with deletions in the 3’ end of the ''gag'' gene. These results suggest there are two regions within BLV necessary for successful RNA encapsidation.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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